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Gamma Knife

Indications For Treatment

 

 

Gamma Knife radiosurgery is used for

treating a wide spectrum of brain disorders

either alone or as an adjunct to

conventional surgery.

 

 


Vascular Malformations
  

  • Arteriovenous Malformations
  • Cavernous Angiomas               
  • AVMs      

The high-energy ionizing radiation of the Gamma Knife rays produces an injury to the inner lining of these malformed vessels causing a clot to form at the site of the injury. This induces a chain of cellular reactions leading to a permanent clogging of the vessel. Hence, the vessel ceases to have blood flowing through it over a period of time (between six months to two years).

 

 

Benign Tumors

  • Meningioma
  • Acoustic Neuromas
  • Pituitary Gland
  • Skull Base Tumors

As a result of the treatment, the DNA structure of the tumor cells is disrupted.  Unable to grow, divide, or reproduce, the tumor cells become "sterile." The tumor cells continue to survive for a time and gradually die a slow death. This phenomenon of “programmed cell death” is termed as "Apoptosis."

 

 

Malignant Tumors 

  • Gliomas 
  • Astrocytomas
  • Glioblastomas    
  • Metastases

The mechanism of action for treating malignant tumors is practically the same for that of benign tumors. The main difference is the faster change/disappearance of the tumor in malignancies because these tumor cells divide and reproduce more quickly than their benign counterparts.

 

 

 

 

Movement Disorders

  • Parkinson’s Disease
  • Essential Tremor

Movement disorders are treated with a single very large dose of radiation directed to a 4mm area in the tremor-producing center of the brain (VML nucleus of the thalamus). The radiation permanently disables the electrical transmission through the nerve cells (neurons) in this region and prevents the tremors within a period of four to eight weeks.

 

 



Trigeminal Neuralgia

 

The high-energy radiation delivered to the nerve in a single session causes the blockage of the ephaptic transmission through the pain-carrying fibers of the nerve.

 

This blocks the transmission of the pain signals to the brain, but preserves the transmission of signals such as the touch, temperature, and pressure sensations. Pain relief may occur immediately or take up to six months to occur.